The fire began around 5:30 Monday morning at the Gilles Apartments on M-26.
Six of the seven apartment units were occupied at the time of the fire, which apparently began in the front upstairs apartment where two teenage boys were staying with their grandmother, according to witnesses.
Another tenant suffered smoke inhalation and a firefighter was reportedly injured while kicking in a door.
All of the other tenants are said to have made it out safely and are currently staying in area hotels or with friends or family.
The cause of the fire remains under investigation.